Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia

نویسندگان

  • Ekaterina Chernyaeva
  • Mikhail Rotkevich
  • Ksenia Krasheninnikova
  • Andrey Yurchenko
  • Anna Vyazovaya
  • Igor Mokrousov
  • Natalia Solovieva
  • Viacheslav Zhuravlev
  • Piotr Yablonsky
  • Stephen J. O’Brien
چکیده

Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Epidemiological and Clinical Survey of Patients with Spondylitis

Background and purpose: Spondylitis is infection of the vertebrae and the intervertebral discs. Mycobacterium Tuberculosis, Brucella, and Pyogenic bacteria are among the major causes of this disease. There are reports on the epidemiology of this disease in Mazandaran, northern Iran. Evidence suggests differences between different types of spondylitis, but there is paucity of information on the ...

متن کامل

Mycobacterium tuberculosis Contaminant Risk on Bone Marrow Aspiration Material from Iliac Bone Patients with Active Tuberculous Spondylitis

There was a concern on Mycobacterium tuberculosis spreading to the bone marrow, when it was applied on tuberculous spine infection. This research aimed to study the probability of using autologous bone marrow as a source of mesenchymal stem cell for patients with tuberculous spondylitis. As many as nine patients with tuberculous spondylitis were used as samples. During the procedure, the verteb...

متن کامل

Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.

Extrapulmonary and, in particular, spinal tuberculosis (TB) constitutes a minor but significant part of the total TB incidence. In spite of this, almost no studies on the genetic diversity and drug resistance of Mycobacterium tuberculosis isolates from spinal TB patients have been published to date. Here, we report results of the first Russian and globally largest molecular study of M. tubercul...

متن کامل

A Case of Pott’s Disease: Cold Abscess in a Haitian Woman Presenting with Chronic Back Pain

Background: Tuberculous spondylitis is a bacterial infection caused by Mycobacterium tuberculosis. This bacteria usually attacks the lungs but can attack any part of the body such as the kidney, spine, and brain. Spine being the most frequently affected site, Spinal TB patients typically present with back pain but other constitutional or pulmonary symptoms may be absent, rendering the diagnosis...

متن کامل

Whole genome sequencing of Mycobacterium tuberculosis SB24 isolated from Sabah, Malaysia

Mycobacterium tuberculosis (M. tuberculosis) is the causative agent of tuberculosis (TB) that causes millions of death every year. We have sequenced the genome of M. tuberculosis isolated from cerebrospinal fluid (CSF) of a patient diagnosed with tuberculous meningitis (TBM). The isolated strain was referred as M. tuberculosis SB24. Genomic DNA of the M. tuberculosis SB24 was extracted and subj...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 24  شماره 

صفحات  -

تاریخ انتشار 2018